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정혜정 ( Jung Hye-Jeong ) - 연세대학교 대학원 간호학과
안수정 ( Ahn Soo-Jung ) - 연세대학교 대학원 간호학과
양유리 ( Yang You-Lee ) - 연세대학교 간호대학
김경아 ( Kim Kyoung-A ) - 연세대학교 대학원 간호학과
신상준 ( Shin Sang-Joon ) - 연세대학교 의과대학
정민규 ( Jung Min-Kyu ) - 연세대학교 의과대학
추상희 ( Chu Sang-Hui ) - 연세대학교 간호대학
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Abstract
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Purpose: This study was conducted to identify the level of oxaliplatin-induced peripheral neuropathy (OIPN), symptoms, distress, and quality of life (QoL) in gastrointestinal (GI) cancer patients and to identify the factors influencing QoL.
Methods: A total of 123 patients were recruited for this cross-sectional study. Surveys used were the Therapy-Induced Neuropathy Assessment Scale (TNAS) for OIPN, the MD Anderson Symptom Inventory (MDASI-GI) for general symptoms associated with gastrointestinal cancer and its treatment, a distress thermometer, and the Euro Quality of Life Questionnaire 5-Dimensional Classification (EQ-5D) for QoL.
Results: The patients were classified into three groups based on their treatment completion time (current, completed less than one year ago, completed more than one year ago). The scores of MDASI-GI and distress were significantly lower in patients who had completed chemotherapy compared to those who were undergoing treatment (p=.04 and .02 respectively). However, TNAS score was significantly higher in patients who completed chemotherapy less than one year ago than the other two groups (p=.001). In multivariate regression models, the OIPN and distress or general symptoms were identified as factors associated with QoL.
Conclusion: In this study, we identified the symptoms that are factors related to the QoL in patients with GI cancer. In particular, the symptoms of OIPN are reported at significantly increased levels for patients who have finished chemotherapy less than one year ago, so efforts to prevent and manage the symptoms of OIPN are needed in this timeframe. To improve QoL of patients with GI cancer, continuous attention and care are required not only during the treatment of cancer but also after the completion of treatment.
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KeyWords
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옥살리플라틴, 항암화학요법, 위장관암, 말초신경병증, 삶의 질
Oxaliplatin, Symptom, Peripheral neuropathy, Distress, Quality of life
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원문 및 링크아웃 정보
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등재저널 정보
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